Drug interactions
Chloroquine + Deutetrabenazine
Severity: Moderate
Chloroquine and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine prolongs the QT interval, and deutetrabenazine can add a small QT effect, mainly at higher exposures. Risk is greater with bradycardia, electrolyte disturbances or congenital long QT.
What this interaction means in plain words
Chloroquine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Obtain baseline ECG and correct potassium and magnesium; monitor ECG in patients with additional QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Chloroquine with Deutetrabenazine?
MediHelp rates the interaction as moderate. Chloroquine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloroquine prolongs the QT interval, and deutetrabenazine can add a small QT effect, mainly at higher exposures. Risk is greater with bradycardia, electrolyte disturbances or congenital long QT.
How serious is the interaction between Chloroquine and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline ECG and correct potassium and magnesium; monitor ECG in patients with additional QT risk factors.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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