Drug interactions
Chloroquine + Dextromethorphan
Severity: Minor
Chloroquine and Dextromethorphan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine can inhibit CYP2D6 and may modestly increase dextromethorphan levels. Clinically relevant effects are uncommon at usual doses.
What this interaction means in plain words
Chloroquine and Dextromethorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroquine belongs to Anti Parasitic; Dextromethorphan belongs to Respiratory.
Why it happens
Inhibition of CYP2D6-mediated dextromethorphan metabolism by chloroquine.
What to do
No routine adjustment is needed; monitor for dizziness or sedation and lower the dextromethorphan dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Dextromethorphan?
MediHelp rates the interaction as minor. Chloroquine and Dextromethorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloroquine can inhibit CYP2D6 and may modestly increase dextromethorphan levels. Clinically relevant effects are uncommon at usual doses.
How serious is the interaction between Chloroquine and Dextromethorphan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for dizziness or sedation and lower the dextromethorphan dose if they occur.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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