Drug interactions
Chloroquine + Doxepin
Severity: Moderate
Chloroquine and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, and doxepin may cause arrhythmia particularly at higher doses or in overdose. Combined use adds to the risk of torsades de pointes.
What this interaction means in plain words
Chloroquine and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Doxepin belongs to Dermatology.
Why it happens
Additive QT prolongation.
What to do
Avoid in patients with long QT or electrolyte disturbances; otherwise obtain an ECG and use the lowest doxepin dose. Correct potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Chloroquine with Doxepin?
MediHelp rates the interaction as moderate. Chloroquine and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, and doxepin may cause arrhythmia particularly at higher doses or in overdose. Combined use adds to the risk of torsades de pointes.
How serious is the interaction between Chloroquine and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with long QT or electrolyte disturbances; otherwise obtain an ECG and use the lowest doxepin dose. Correct potassium and magnesium.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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