Drug interactions
Chloroquine + Duvelisib
Severity: Minor
Chloroquine and Duvelisib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib is a CYP3A4 inhibitor and may raise chloroquine levels. Higher exposure could increase chloroquine adverse effects such as gastrointestinal upset and QT prolongation.
What this interaction means in plain words
Chloroquine and Duvelisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroquine belongs to Anti Parasitic; Duvelisib belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4 and may reduce the metabolic clearance of chloroquine.
What to do
Monitor for chloroquine toxicity, including QT prolongation if other risk factors exist. Consider an ECG when other QT-prolonging drugs are also being given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Chloroquine with Duvelisib?
MediHelp rates the interaction as minor. Chloroquine and Duvelisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Duvelisib is a CYP3A4 inhibitor and may raise chloroquine levels. Higher exposure could increase chloroquine adverse effects such as gastrointestinal upset and QT prolongation.
How serious is the interaction between Chloroquine and Duvelisib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for chloroquine toxicity, including QT prolongation if other risk factors exist. Consider an ECG when other QT-prolonging drugs are also being given.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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