Drug interactions
Chloroquine + Histrelin
Severity: Moderate
Chloroquine and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist causing androgen deprivation, can prolong the QT interval. Combined with chloroquine, which also prolongs QT, the risk of torsades de pointes may increase.
What this interaction means in plain words
Chloroquine and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QT prolongation; androgen deprivation therapy affects cardiac repolarization.
What to do
Perform a baseline ECG and monitor QTc and electrolytes during co-therapy. Consider an alternative antimalarial or non-QT-prolonging agent if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Chloroquine with Histrelin?
MediHelp rates the interaction as moderate. Chloroquine and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist causing androgen deprivation, can prolong the QT interval. Combined with chloroquine, which also prolongs QT, the risk of torsades de pointes may increase.
How serious is the interaction between Chloroquine and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform a baseline ECG and monitor QTc and electrolytes during co-therapy. Consider an alternative antimalarial or non-QT-prolonging agent if QTc becomes markedly prolonged.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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