Drug interactions
Chloroquine + Hydrocodone
Severity: Minor
Chloroquine and Hydrocodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine may inhibit CYP2D6 and reduce conversion of hydrocodone to hydromorphone. The clinical effect is probably small, since hydrocodone is active itself and CYP3A4 is its main pathway.
What this interaction means in plain words
Chloroquine and Hydrocodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroquine belongs to Anti Parasitic; Hydrocodone belongs to Musculoskeletal.
Why it happens
Chloroquine weakly inhibits CYP2D6, reducing O-demethylation of hydrocodone to hydromorphone.
What to do
No routine adjustment is needed. Reassess analgesic response if pain control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Hydrocodone?
MediHelp rates the interaction as minor. Chloroquine and Hydrocodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloroquine may inhibit CYP2D6 and reduce conversion of hydrocodone to hydromorphone. The clinical effect is probably small, since hydrocodone is active itself and CYP3A4 is its main pathway.
How serious is the interaction between Chloroquine and Hydrocodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Reassess analgesic response if pain control changes.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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