Drug interactions
Chloroquine + Ipratropium-salbutamol
Severity: Moderate
Chloroquine and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine prolongs the QT interval and can cause arrhythmias. Salbutamol can add to this through beta-agonist effects and hypokalemia, especially at high doses. The risk is mainly relevant in patients with other QT risk factors.
What this interaction means in plain words
Chloroquine and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with salbutamol-induced hypokalemia increasing arrhythmia susceptibility.
What to do
Check baseline ECG and potassium and magnesium levels in patients at risk. Avoid high-dose nebulised salbutamol where possible during chloroquine therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Chloroquine and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloroquine prolongs the QT interval and can cause arrhythmias. Salbutamol can add to this through beta-agonist effects and hypokalemia, especially at high doses. The risk is mainly relevant in patients with other QT risk factors.
How serious is the interaction between Chloroquine and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and potassium and magnesium levels in patients at risk. Avoid high-dose nebulised salbutamol where possible during chloroquine therapy.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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