Drug interactions
Chloroquine + Lapatinib
Severity: Moderate
Chloroquine and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both lapatinib and chloroquine can prolong the QT interval, so combined use may add to the risk of ventricular arrhythmia. The risk is greater with electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Chloroquine and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Lapatinib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG, correct potassium and magnesium, and monitor QTc periodically. Consider an alternative antimalarial if QTc exceeds acceptable limits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Chloroquine with Lapatinib?
MediHelp rates the interaction as moderate. Chloroquine and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both lapatinib and chloroquine can prolong the QT interval, so combined use may add to the risk of ventricular arrhythmia. The risk is greater with electrolyte disturbance or cardiac disease.
How serious is the interaction between Chloroquine and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct potassium and magnesium, and monitor QTc periodically. Consider an alternative antimalarial if QTc exceeds acceptable limits.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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