Drug interactions
Chloroquine + Mexiletine
Severity: Moderate
Chloroquine and Mexiletine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine may raise mexiletine concentrations by inhibiting CYP2D6. Mexiletine toxicity includes tremor, dizziness, nausea, and proarrhythmia.
What this interaction means in plain words
Chloroquine and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Mexiletine belongs to Cardiovascular.
Why it happens
Chloroquine inhibits CYP2D6 metabolism of mexiletine.
What to do
Monitor for neurological and gastrointestinal toxicity and obtain an ECG. Adjust the mexiletine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Frequently asked questions
Can I take Chloroquine with Mexiletine?
MediHelp rates the interaction as moderate. Chloroquine and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloroquine may raise mexiletine concentrations by inhibiting CYP2D6. Mexiletine toxicity includes tremor, dizziness, nausea, and proarrhythmia.
How serious is the interaction between Chloroquine and Mexiletine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurological and gastrointestinal toxicity and obtain an ECG. Adjust the mexiletine dose as needed.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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