Drug interactions
Chloroquine + Mifepristone
Severity: Moderate
Chloroquine and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may increase chloroquine concentrations. Both drugs have been associated with QT prolongation, so higher exposure could add to arrhythmia risk, especially with chronic mifepristone use.
What this interaction means in plain words
Chloroquine and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Mifepristone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by mifepristone reduces chloroquine metabolism, with additive QT effects.
What to do
Obtain a baseline ECG and monitor QTc, and correct potassium and magnesium abnormalities. Consider an alternative antimalarial if the QT interval becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Chloroquine with Mifepristone?
MediHelp rates the interaction as moderate. Chloroquine and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may increase chloroquine concentrations. Both drugs have been associated with QT prolongation, so higher exposure could add to arrhythmia risk, especially with chronic mifepristone use.
How serious is the interaction between Chloroquine and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, and correct potassium and magnesium abnormalities. Consider an alternative antimalarial if the QT interval becomes prolonged.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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