Drug interactions
Chloroquine + Mitotane
Severity: Moderate
Chloroquine and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and may lower chloroquine concentrations, with induction persisting for weeks after mitotane is stopped. This may reduce antimalarial or anti-rheumatic efficacy.
What this interaction means in plain words
Chloroquine and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Mitotane belongs to Oncology.
Why it happens
Mitotane induces CYP3A4, increasing chloroquine metabolism.
What to do
Monitor clinical response and consider an alternative agent if chloroquine efficacy is critical, such as in malaria treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Chloroquine with Mitotane?
MediHelp rates the interaction as moderate. Chloroquine and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and may lower chloroquine concentrations, with induction persisting for weeks after mitotane is stopped. This may reduce antimalarial or anti-rheumatic efficacy.
How serious is the interaction between Chloroquine and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider an alternative agent if chloroquine efficacy is critical, such as in malaria treatment.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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