Drug interactions
Chloroquine + Oliceridine
Severity: Moderate
Chloroquine and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine inhibits CYP2D6, which contributes to oliceridine clearance. Increased oliceridine exposure could raise the risk of sedation and respiratory depression.
What this interaction means in plain words
Chloroquine and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Oliceridine belongs to Musculoskeletal.
Why it happens
Chloroquine inhibits CYP2D6 and may reduce the metabolic clearance of oliceridine.
What to do
Monitor for sedation and respiratory depression and titrate oliceridine to effect. If chloroquine is stopped, reassess the dose because opioid effect may decrease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Chloroquine with Oliceridine?
MediHelp rates the interaction as moderate. Chloroquine and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloroquine inhibits CYP2D6, which contributes to oliceridine clearance. Increased oliceridine exposure could raise the risk of sedation and respiratory depression.
How serious is the interaction between Chloroquine and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and titrate oliceridine to effect. If chloroquine is stopped, reassess the dose because opioid effect may decrease.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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