Drug interactions
Chloroquine + Sertraline
Severity: Moderate
Chloroquine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline carries a low but recognised risk of QT prolongation and chloroquine prolongs the QT interval more clearly. Combined use may modestly increase arrhythmic risk, particularly with other risk factors.
What this interaction means in plain words
Chloroquine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Obtain an ECG in patients with cardiac risk factors and correct electrolyte abnormalities. Monitor QTc if other QT-prolonging drugs are also used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Chloroquine with Sertraline?
MediHelp rates the interaction as moderate. Chloroquine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline carries a low but recognised risk of QT prolongation and chloroquine prolongs the QT interval more clearly. Combined use may modestly increase arrhythmic risk, particularly with other risk factors.
How serious is the interaction between Chloroquine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG in patients with cardiac risk factors and correct electrolyte abnormalities. Monitor QTc if other QT-prolonging drugs are also used.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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