Drug interactions
Chloroquine + Tamsulosin
Severity: Minor
Chloroquine and Tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine can inhibit CYP2D6 and may increase tamsulosin exposure, with a risk of dizziness and orthostatic hypotension. The effect is likely modest.
What this interaction means in plain words
Chloroquine and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroquine belongs to Anti Parasitic; Tamsulosin belongs to Genitourinary.
Why it happens
Inhibition of CYP2D6 metabolism of tamsulosin by chloroquine.
What to do
Monitor for orthostatic symptoms during combined use. Reduce the tamsulosin dose if hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Tamsulosin?
MediHelp rates the interaction as minor. Chloroquine and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloroquine can inhibit CYP2D6 and may increase tamsulosin exposure, with a risk of dizziness and orthostatic hypotension. The effect is likely modest.
How serious is the interaction between Chloroquine and Tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic symptoms during combined use. Reduce the tamsulosin dose if hypotension develops.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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