Drug interactions
Chloroquine + Tetrabenazine
Severity: Moderate
Chloroquine and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both chloroquine and tetrabenazine can prolong the QTc interval. Used together they may add to the risk of torsades de pointes, especially with electrolyte disturbances or underlying heart disease.
What this interaction means in plain words
Chloroquine and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through cardiac repolarization effects (hERG potassium channel blockade).
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining, then monitor the QTc during therapy. Avoid the combination in patients with congenital long QT or a prolonged baseline QTc.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Chloroquine with Tetrabenazine?
MediHelp rates the interaction as moderate. Chloroquine and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both chloroquine and tetrabenazine can prolong the QTc interval. Used together they may add to the risk of torsades de pointes, especially with electrolyte disturbances or underlying heart disease.
How serious is the interaction between Chloroquine and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining, then monitor the QTc during therapy. Avoid the combination in patients with congenital long QT or a prolonged baseline QTc.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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