Drug interactions
Chloroquine + Vardenafil
Severity: Moderate
Chloroquine and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both vardenafil and chloroquine can prolong the QT interval. Combining them may increase the risk of ventricular arrhythmias such as torsades de pointes, particularly with other predisposing factors.
What this interaction means in plain words
Chloroquine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Vardenafil belongs to Genitourinary.
Why it happens
Additive QTc prolongation through effects on cardiac repolarisation.
What to do
Avoid combining in patients with known QT prolongation or other risk factors; obtain a baseline ECG and correct electrolytes if concurrent use is necessary.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Vardenafil?
MediHelp rates the interaction as moderate. Chloroquine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both vardenafil and chloroquine can prolong the QT interval. Combining them may increase the risk of ventricular arrhythmias such as torsades de pointes, particularly with other predisposing factors.
How serious is the interaction between Chloroquine and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining in patients with known QT prolongation or other risk factors; obtain a baseline ECG and correct electrolytes if concurrent use is necessary.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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