Drug interactions
Chlorothiazide + Digoxin
Severity: Moderate
Chlorothiazide and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide can cause hypokalemia and hypomagnesemia, which sensitize the heart to digoxin and increase the risk of arrhythmias and toxicity.
What this interaction means in plain words
Chlorothiazide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Why it happens
Diuretic-induced hypokalemia and hypomagnesemia enhance myocardial sensitivity to digoxin.
What to do
Monitor potassium and magnesium regularly and replace as needed; check digoxin level if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Digoxin?
MediHelp rates the interaction as moderate. Chlorothiazide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide can cause hypokalemia and hypomagnesemia, which sensitize the heart to digoxin and increase the risk of arrhythmias and toxicity.
How serious is the interaction between Chlorothiazide and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium regularly and replace as needed; check digoxin level if toxicity is suspected.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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