Drug interactions
Chlorothiazide + Glipizide
Severity: Moderate
Chlorothiazide and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide may increase blood glucose and reduce the effectiveness of glipizide. Patients with diabetes can lose glycemic control, especially with higher diuretic doses or electrolyte disturbances.
What this interaction means in plain words
Chlorothiazide and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Glipizide belongs to Endocrine.
Why it happens
Thiazide-induced hypokalemia and reduced insulin secretion plus increased insulin resistance oppose sulfonylurea action.
What to do
Monitor blood glucose and serum potassium when starting or changing chlorothiazide. Adjust the glipizide dose if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Glipizide?
MediHelp rates the interaction as moderate. Chlorothiazide and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide may increase blood glucose and reduce the effectiveness of glipizide. Patients with diabetes can lose glycemic control, especially with higher diuretic doses or electrolyte disturbances.
How serious is the interaction between Chlorothiazide and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium when starting or changing chlorothiazide. Adjust the glipizide dose if hyperglycemia develops.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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