Drug interactions
Chlorothiazide + Hydrochlorothiazide-irbesartan
Severity: Moderate
Chlorothiazide and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using chlorothiazide with hydrochlorothiazide duplicates diuretic therapy and increases the risk of hypokalemia, hyponatremia and volume depletion. There is little added benefit.
What this interaction means in plain words
Chlorothiazide and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Additive inhibition of the sodium-chloride cotransporter in the distal tubule.
What to do
Avoid combining two thiazides; use one agent and monitor electrolytes and renal function if overlap occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Chlorothiazide and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using chlorothiazide with hydrochlorothiazide duplicates diuretic therapy and increases the risk of hypokalemia, hyponatremia and volume depletion. There is little added benefit.
How serious is the interaction between Chlorothiazide and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazides; use one agent and monitor electrolytes and renal function if overlap occurs.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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