Drug interactions
Chlorothiazide + Indacaterol
Severity: Moderate
Chlorothiazide and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics such as chlorothiazide lower serum potassium, and beta-2 agonists can drive potassium into cells. Together hypokalemia may be amplified, and this can provoke ECG changes and arrhythmias, especially with high doses of indacaterol.
What this interaction means in plain words
Chlorothiazide and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Indacaterol belongs to Respiratory.
Why it happens
Additive hypokalemia from renal potassium loss and beta-2-mediated intracellular potassium shift.
What to do
Monitor serum potassium periodically, replace potassium or add a potassium-sparing agent when needed, and take extra care in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Indacaterol?
MediHelp rates the interaction as moderate. Chlorothiazide and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics such as chlorothiazide lower serum potassium, and beta-2 agonists can drive potassium into cells. Together hypokalemia may be amplified, and this can provoke ECG changes and arrhythmias, especially with high doses of indacaterol.
How serious is the interaction between Chlorothiazide and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, replace potassium or add a potassium-sparing agent when needed, and take extra care in patients with cardiac disease.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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