Drug interactions
Chlorothiazide + Mometasone
Severity: Minor
Chlorothiazide and Mometasone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids with mineralocorticoid activity and thiazide diuretics both promote potassium loss, so combined use can contribute to hypokalemia. With inhaled mometasone the systemic exposure is low and the effect is usually small.
What this interaction means in plain words
Chlorothiazide and Mometasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Mometasone belongs to Respiratory.
Why it happens
Additive renal potassium wasting from thiazide-induced distal delivery of sodium and corticosteroid mineralocorticoid effects.
What to do
Monitor serum potassium, particularly with high doses or other hypokalemia risk factors, and supplement if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mometasone
- Mometasone + Ritonavir Major
- Atazanavir + Mometasone Moderate
- Clarithromycin + Mometasone Moderate
- Cobicistat + Mometasone Moderate
- Darunavir + Mometasone Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mometasone Moderate
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Mometasone?
MediHelp rates the interaction as minor. Chlorothiazide and Mometasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids with mineralocorticoid activity and thiazide diuretics both promote potassium loss, so combined use can contribute to hypokalemia. With inhaled mometasone the systemic exposure is low and the effect is usually small.
How serious is the interaction between Chlorothiazide and Mometasone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly with high doses or other hypokalemia risk factors, and supplement if needed.
What other medicines interact with Mometasone?
MediHelp also lists interactions of Mometasone with, for example, Ritonavir, Atazanavir, Clarithromycin. The full list is on the Mometasone page.
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