Drug interactions
Chlorothiazide + Tiotropium-olodaterol
Severity: Moderate
Chlorothiazide and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide lowers serum potassium, and beta2-agonists can further reduce it by intracellular shift. Hypokalemia may promote arrhythmias, particularly in patients with cardiac disease. The effect from inhaled olodaterol is usually modest.
What this interaction means in plain words
Chlorothiazide and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive hypokalemia from renal potassium loss and beta2-mediated potassium shift.
What to do
Monitor serum potassium and magnesium periodically and replace as needed, especially in patients with heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Chlorothiazide and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide lowers serum potassium, and beta2-agonists can further reduce it by intracellular shift. Hypokalemia may promote arrhythmias, particularly in patients with cardiac disease. The effect from inhaled olodaterol is usually modest.
How serious is the interaction between Chlorothiazide and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium periodically and replace as needed, especially in patients with heart disease.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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