Drug interactions
Chlorpheniramine + Crofelemer
Severity: Minor
Chlorpheniramine and Crofelemer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer may inhibit CYP3A4 in the gut, which could modestly raise chlorpheniramine exposure. Systemic effects are unlikely because crofelemer is barely absorbed, so the clinical impact is probably small.
What this interaction means in plain words
Chlorpheniramine and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpheniramine belongs to Respiratory; Crofelemer belongs to Gastrointestinal Tract.
Why it happens
Possible inhibition of intestinal CYP3A4 by crofelemer, reducing first-pass metabolism of chlorpheniramine.
What to do
No routine adjustment is needed. Watch for increased drowsiness or anticholinergic effects when starting crofelemer.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpheniramine
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Chlorpheniramine with Crofelemer?
MediHelp rates the interaction as minor. Chlorpheniramine and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer may inhibit CYP3A4 in the gut, which could modestly raise chlorpheniramine exposure. Systemic effects are unlikely because crofelemer is barely absorbed, so the clinical impact is probably small.
How serious is the interaction between Chlorpheniramine and Crofelemer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for increased drowsiness or anticholinergic effects when starting crofelemer.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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