Drug interactions
Chlorpheniramine + Fenfluramine
Severity: Moderate
Chlorpheniramine and Fenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine causes sedation while fenfluramine can cause somnolence, fatigue or occasionally agitation, so the net effect is unpredictable. Fenfluramine labeling advises caution with other CNS depressants because sedation may be additive.
What this interaction means in plain words
Chlorpheniramine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Fenfluramine belongs to Central Nervous System.
Why it happens
Additive CNS depression is likely, and fenfluramine's serotonergic activity may modify the response; the exact interaction is not well characterized.
What to do
Monitor for excessive drowsiness, particularly when starting or adjusting either drug. Counsel patients about driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpheniramine and Fenfluramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorpheniramine
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Chlorpheniramine with Fenfluramine?
MediHelp rates the interaction as moderate. Chlorpheniramine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine causes sedation while fenfluramine can cause somnolence, fatigue or occasionally agitation, so the net effect is unpredictable. Fenfluramine labeling advises caution with other CNS depressants because sedation may be additive.
How serious is the interaction between Chlorpheniramine and Fenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness, particularly when starting or adjusting either drug. Counsel patients about driving and machinery.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
