Drug interactions
Chlorpheniramine + Levoketoconazole
Severity: Moderate
Chlorpheniramine and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and may increase chlorpheniramine exposure, leading to more sedation and anticholinergic effects. Chlorpheniramine has a wide margin of safety, so the effect is generally manageable.
What this interaction means in plain words
Chlorpheniramine and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Levoketoconazole belongs to Endocrine.
Why it happens
Strong CYP3A4 inhibition reduces chlorpheniramine clearance.
What to do
Monitor for excess sedation, dry mouth and urinary retention and consider a lower dose or a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Chlorpheniramine with Levoketoconazole?
MediHelp rates the interaction as moderate. Chlorpheniramine and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and may increase chlorpheniramine exposure, leading to more sedation and anticholinergic effects. Chlorpheniramine has a wide margin of safety, so the effect is generally manageable.
How serious is the interaction between Chlorpheniramine and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, dry mouth and urinary retention and consider a lower dose or a non-sedating antihistamine.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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