Drug interactions
Chlorpheniramine + Mirtazapine
Severity: Moderate
Chlorpheniramine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a sedating antihistamine and mirtazapine is strongly antihistaminic, so combined use can cause pronounced drowsiness and impaired performance. Anticholinergic effects such as dry mouth or confusion may also be more evident in older adults.
What this interaction means in plain words
Chlorpheniramine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive H1 receptor antagonism and CNS depression.
What to do
Use a non-sedating antihistamine where possible. If combined, warn about driving and alcohol and monitor older patients for confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Mirtazapine?
MediHelp rates the interaction as moderate. Chlorpheniramine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a sedating antihistamine and mirtazapine is strongly antihistaminic, so combined use can cause pronounced drowsiness and impaired performance. Anticholinergic effects such as dry mouth or confusion may also be more evident in older adults.
How serious is the interaction between Chlorpheniramine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-sedating antihistamine where possible. If combined, warn about driving and alcohol and monitor older patients for confusion.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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