Drug interactions
Chlorpheniramine + Modafinil
Severity: Minor
Chlorpheniramine and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine causes sedation while modafinil promotes wakefulness, so their effects oppose each other. Impairment of alertness may persist despite apparent reduction in drowsiness.
What this interaction means in plain words
Chlorpheniramine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpheniramine belongs to Respiratory; Modafinil belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on CNS arousal (H1 antagonism versus wake-promoting action).
What to do
Warn the patient about residual impairment when driving or operating machinery; use a non-sedating antihistamine where possible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Modafinil?
MediHelp rates the interaction as minor. Chlorpheniramine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorpheniramine causes sedation while modafinil promotes wakefulness, so their effects oppose each other. Impairment of alertness may persist despite apparent reduction in drowsiness.
How serious is the interaction between Chlorpheniramine and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about residual impairment when driving or operating machinery; use a non-sedating antihistamine where possible.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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