Drug interactions
Chlorpheniramine + Oxycodone
Severity: Moderate
Chlorpheniramine and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a sedating first-generation antihistamine, and with oxycodone it increases drowsiness and impairs psychomotor performance. Elderly patients are particularly at risk of confusion and falls.
What this interaction means in plain words
Chlorpheniramine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS depression.
What to do
Warn patients about increased drowsiness and avoid driving; consider a non-sedating antihistamine if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Oxycodone?
MediHelp rates the interaction as moderate. Chlorpheniramine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a sedating first-generation antihistamine, and with oxycodone it increases drowsiness and impairs psychomotor performance. Elderly patients are particularly at risk of confusion and falls.
How serious is the interaction between Chlorpheniramine and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about increased drowsiness and avoid driving; consider a non-sedating antihistamine if one is needed.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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