Drug interactions
Chlorpromazine + Cyclobenzaprine
Severity: Moderate
Chlorpromazine and Cyclobenzaprine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and have strong anticholinergic properties, so combined use can lead to marked drowsiness, confusion, constipation, urinary retention and hypotension. Chlorpromazine may also lower the seizure threshold and prolong QT, adding to the risk.
What this interaction means in plain words
Chlorpromazine and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Cyclobenzaprine belongs to Musculoskeletal.
Why it happens
Additive CNS depressant, anticholinergic and hypotensive effects.
What to do
Monitor sedation, anticholinergic symptoms and blood pressure, using the lowest effective doses. Avoid in elderly patients where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Cyclobenzaprine?
MediHelp rates the interaction as moderate. Chlorpromazine and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and have strong anticholinergic properties, so combined use can lead to marked drowsiness, confusion, constipation, urinary retention and hypotension. Chlorpromazine may also lower the seizure threshold and prolong QT, adding to the risk.
How serious is the interaction between Chlorpromazine and Cyclobenzaprine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, anticholinergic symptoms and blood pressure, using the lowest effective doses. Avoid in elderly patients where possible.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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