Drug interactions
Chlorpromazine + Degarelix
Severity: Moderate
Chlorpromazine and Degarelix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy can prolong the QT interval, and chlorpromazine has additional QT-prolonging potential. Together they may increase the risk of arrhythmia.
What this interaction means in plain words
Chlorpromazine and Degarelix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Degarelix belongs to Endocrine.
Why it happens
Additive QT prolongation, with androgen deprivation affecting cardiac repolarization.
What to do
Obtain a baseline ECG and correct electrolytes. Monitor QTc periodically, or choose a less QT-active antipsychotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Chlorpromazine with Degarelix?
MediHelp rates the interaction as moderate. Chlorpromazine and Degarelix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy can prolong the QT interval, and chlorpromazine has additional QT-prolonging potential. Together they may increase the risk of arrhythmia.
How serious is the interaction between Chlorpromazine and Degarelix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes. Monitor QTc periodically, or choose a less QT-active antipsychotic.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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