Drug interactions
Chlorpromazine + Diphenoxylate
Severity: Moderate
Chlorpromazine and Diphenoxylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid and can cause CNS depression, which may add to chlorpromazine sedation. Anticholinergic effects from both agents may also slow gut motility.
What this interaction means in plain words
Chlorpromazine and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Diphenoxylate belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression and additive anticholinergic effects.
What to do
Counsel patients on drowsiness and avoid exceeding recommended doses. Monitor for excessive sedation and for constipation or ileus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Chlorpromazine with Diphenoxylate?
MediHelp rates the interaction as moderate. Chlorpromazine and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid and can cause CNS depression, which may add to chlorpromazine sedation. Anticholinergic effects from both agents may also slow gut motility.
How serious is the interaction between Chlorpromazine and Diphenoxylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on drowsiness and avoid exceeding recommended doses. Monitor for excessive sedation and for constipation or ileus.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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