Drug interactions
Chlorpromazine + Dobutamine
Severity: Moderate
Chlorpromazine and Dobutamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine blocks alpha-adrenergic receptors and can cause hypotension and QT prolongation, which may blunt vasoconstrictor effects and add to arrhythmia risk with dobutamine. The combination can therefore cause hemodynamic instability.
What this interaction means in plain words
Chlorpromazine and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Dobutamine belongs to Cardiovascular.
Why it happens
Alpha-adrenergic blockade and QT prolongation by chlorpromazine combined with beta-agonist cardiac stimulation.
What to do
Monitor blood pressure and ECG, and correct potassium and magnesium before and during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dobutamine
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Dobutamine?
MediHelp rates the interaction as moderate. Chlorpromazine and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine blocks alpha-adrenergic receptors and can cause hypotension and QT prolongation, which may blunt vasoconstrictor effects and add to arrhythmia risk with dobutamine. The combination can therefore cause hemodynamic instability.
How serious is the interaction between Chlorpromazine and Dobutamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and ECG, and correct potassium and magnesium before and during therapy.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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