Drug interactions
Chlorpromazine + Empagliflozin-metformin
Severity: Moderate
Chlorpromazine and Empagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine, especially at higher doses, can raise blood glucose and reduce the effect of antidiabetic drugs. Glucose may fall again if chlorpromazine is withdrawn, risking hypoglycemia if doses were raised.
What this interaction means in plain words
Chlorpromazine and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Empagliflozin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: phenothiazines can reduce insulin secretion and sensitivity, causing hyperglycemia.
What to do
Monitor blood glucose when starting, changing or stopping chlorpromazine, and adjust antidiabetic doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Empagliflozin-metformin?
MediHelp rates the interaction as moderate. Chlorpromazine and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine, especially at higher doses, can raise blood glucose and reduce the effect of antidiabetic drugs. Glucose may fall again if chlorpromazine is withdrawn, risking hypoglycemia if doses were raised.
How serious is the interaction between Chlorpromazine and Empagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, changing or stopping chlorpromazine, and adjust antidiabetic doses accordingly.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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