Drug interactions
Chlorpromazine + Etrasimod
Severity: Major
Chlorpromazine and Etrasimod: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can transiently slow heart rate and delay AV conduction on initiation, while chlorpromazine prolongs the QT interval. Combined use may raise the risk of arrhythmia including torsades de pointes.
What this interaction means in plain words
Chlorpromazine and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive bradycardic effect with QT prolongation, favoring torsades.
What to do
Obtain a baseline ECG and monitor heart rate and QTc when starting etrasimod; consider cardiology advice or an alternative to chlorpromazine in high-risk patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Chlorpromazine with Etrasimod?
MediHelp rates the interaction as major. Chlorpromazine and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod can transiently slow heart rate and delay AV conduction on initiation, while chlorpromazine prolongs the QT interval. Combined use may raise the risk of arrhythmia including torsades de pointes.
How serious is the interaction between Chlorpromazine and Etrasimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor heart rate and QTc when starting etrasimod; consider cardiology advice or an alternative to chlorpromazine in high-risk patients.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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