Drug interactions
Chlorpromazine + Ezogabine
Severity: Moderate
Chlorpromazine and Ezogabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine prolongs the QT interval, and ezogabine has been associated with modest QT prolongation. Combined use may increase the risk of ventricular arrhythmia. Ezogabine can also cause urinary retention and sedation, which may be compounded by chlorpromazine's anticholinergic and sedative effects.
What this interaction means in plain words
Chlorpromazine and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Ezogabine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with additive sedative and anticholinergic effects.
What to do
Check a baseline ECG and monitor QTc, keeping potassium and magnesium normal. Monitor for sedation and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Chlorpromazine with Ezogabine?
MediHelp rates the interaction as moderate. Chlorpromazine and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine prolongs the QT interval, and ezogabine has been associated with modest QT prolongation. Combined use may increase the risk of ventricular arrhythmia. Ezogabine can also cause urinary retention and sedation, which may be compounded by chlorpromazine's anticholinergic and sedative effects.
How serious is the interaction between Chlorpromazine and Ezogabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor QTc, keeping potassium and magnesium normal. Monitor for sedation and urinary retention.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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