Drug interactions
Chlorpromazine + Fesoterodine
Severity: Moderate
Chlorpromazine and Fesoterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have antimuscarinic activity, so combined use can increase dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, especially in older adults. Reduced gastric motility could also alter chlorpromazine absorption.
What this interaction means in plain words
Chlorpromazine and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Fesoterodine belongs to Genitourinary.
Why it happens
Additive anticholinergic pharmacodynamic effects at muscarinic receptors.
What to do
Monitor for anticholinergic toxicity such as constipation, urinary retention and cognitive changes, and reduce overall anticholinergic burden where possible. Review the need for both drugs in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Fesoterodine?
MediHelp rates the interaction as moderate. Chlorpromazine and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have antimuscarinic activity, so combined use can increase dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, especially in older adults. Reduced gastric motility could also alter chlorpromazine absorption.
How serious is the interaction between Chlorpromazine and Fesoterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity such as constipation, urinary retention and cognitive changes, and reduce overall anticholinergic burden where possible. Review the need for both drugs in elderly patients.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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