Drug interactions
Chlorpromazine + Fingolimod
Severity: Major
Chlorpromazine and Fingolimod: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod causes bradycardia after the first dose and has been associated with QT prolongation, while chlorpromazine also prolongs the QT interval. Together they increase the risk of torsades de pointes, particularly at treatment initiation.
What this interaction means in plain words
Chlorpromazine and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Fingolimod belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with fingolimod-induced bradycardia increasing susceptibility to torsades.
What to do
Avoid starting fingolimod in patients on chlorpromazine where possible; if unavoidable, seek cardiology advice and use ECG monitoring at initiation and overnight observation when indicated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Fingolimod?
MediHelp rates the interaction as major. Chlorpromazine and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fingolimod causes bradycardia after the first dose and has been associated with QT prolongation, while chlorpromazine also prolongs the QT interval. Together they increase the risk of torsades de pointes, particularly at treatment initiation.
How serious is the interaction between Chlorpromazine and Fingolimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting fingolimod in patients on chlorpromazine where possible; if unavoidable, seek cardiology advice and use ECG monitoring at initiation and overnight observation when indicated.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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