Drug interactions
Chlorpromazine + Fluticasone-salmeterol
Severity: Moderate
Chlorpromazine and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine can prolong the QT interval and salmeterol may add to this effect, particularly with hypokalemia at higher doses. This may modestly raise arrhythmia risk in susceptible patients.
What this interaction means in plain words
Chlorpromazine and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Additive QTc prolongation, with beta-2 agonist-induced hypokalemia as a possible contributor.
What to do
Check ECG and potassium in patients with cardiac risk factors and keep salmeterol at the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Chlorpromazine and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine can prolong the QT interval and salmeterol may add to this effect, particularly with hypokalemia at higher doses. This may modestly raise arrhythmia risk in susceptible patients.
How serious is the interaction between Chlorpromazine and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and potassium in patients with cardiac risk factors and keep salmeterol at the lowest effective dose.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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