Drug interactions
Chlorpromazine + Ganaxolone
Severity: Moderate
Chlorpromazine and Ganaxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taking them together can deepen sedation, drowsiness and impair psychomotor performance. The effect is most relevant when doses are being started or increased.
What this interaction means in plain words
Chlorpromazine and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Ganaxolone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects (GABA-A positive modulation by ganaxolone plus antihistaminic and antidopaminergic sedation from chlorpromazine).
What to do
Monitor for excessive sedation and reduced alertness, and consider lowering the dose of one agent if oversedation occurs. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Ganaxolone
Frequently asked questions
Can I take Chlorpromazine with Ganaxolone?
MediHelp rates the interaction as moderate. Chlorpromazine and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taking them together can deepen sedation, drowsiness and impair psychomotor performance. The effect is most relevant when doses are being started or increased.
How serious is the interaction between Chlorpromazine and Ganaxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduced alertness, and consider lowering the dose of one agent if oversedation occurs. Advise patients to avoid driving and alcohol.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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