Drug interactions
Chlorpromazine + Glyburide-metformin
Severity: Moderate
Chlorpromazine and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine can cause hyperglycemia and impair glucose control, particularly at higher doses. This may weaken the effect of glyburide and metformin, and hypoglycemia may occur when it is withdrawn.
What this interaction means in plain words
Chlorpromazine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Glyburide-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through reduced insulin secretion and increased insulin resistance.
What to do
Monitor blood glucose when starting, changing or stopping chlorpromazine and adjust antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Glyburide-metformin?
MediHelp rates the interaction as moderate. Chlorpromazine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine can cause hyperglycemia and impair glucose control, particularly at higher doses. This may weaken the effect of glyburide and metformin, and hypoglycemia may occur when it is withdrawn.
How serious is the interaction between Chlorpromazine and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, changing or stopping chlorpromazine and adjust antidiabetic doses as needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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