Drug interactions
Chlorpromazine + Insulin degludec-liraglutide
Severity: Moderate
Chlorpromazine and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine can alter glucose levels, most often causing hyperglycemia, which may reduce the effect of insulin degludec-liraglutide. Glycemic control can become less predictable when the phenothiazine is started or changed.
What this interaction means in plain words
Chlorpromazine and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Phenothiazines may reduce insulin secretion and sensitivity, giving variable effects on glucose that oppose antidiabetic drugs.
What to do
Monitor blood glucose when chlorpromazine is started, changed or stopped, and adjust the antidiabetic regimen accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Chlorpromazine and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine can alter glucose levels, most often causing hyperglycemia, which may reduce the effect of insulin degludec-liraglutide. Glycemic control can become less predictable when the phenothiazine is started or changed.
How serious is the interaction between Chlorpromazine and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when chlorpromazine is started, changed or stopped, and adjust the antidiabetic regimen accordingly.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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