Drug interactions
Chlorpromazine + Isoflurane
Severity: Moderate
Chlorpromazine and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval, and chlorpromazine adds to this effect, so arrhythmia risk during anesthesia may rise. Additive hypotension and CNS depression are also expected.
What this interaction means in plain words
Chlorpromazine and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Isoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus additive vasodilatory and central depressant effects.
What to do
Tell the anesthesia team about chlorpromazine use before surgery and monitor ECG and blood pressure throughout. Correct electrolyte abnormalities beforehand and avoid other QT-prolonging drugs perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Chlorpromazine with Isoflurane?
MediHelp rates the interaction as moderate. Chlorpromazine and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval, and chlorpromazine adds to this effect, so arrhythmia risk during anesthesia may rise. Additive hypotension and CNS depression are also expected.
How serious is the interaction between Chlorpromazine and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about chlorpromazine use before surgery and monitor ECG and blood pressure throughout. Correct electrolyte abnormalities beforehand and avoid other QT-prolonging drugs perioperatively.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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