Drug interactions
Chlorpromazine + Oxybutynin
Severity: Moderate
Chlorpromazine and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so combined use can increase dry mouth, constipation, urinary retention, blurred vision, confusion and heat intolerance. Older adults and patients with cognitive impairment are at greatest risk of delirium and falls.
What this interaction means in plain words
Chlorpromazine and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Oxybutynin belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects at central and peripheral receptors.
What to do
Monitor for anticholinergic toxicity such as constipation, urinary retention and confusion, especially in elderly patients. Use the lowest effective doses or consider a less anticholinergic alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Oxybutynin?
MediHelp rates the interaction as moderate. Chlorpromazine and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combined use can increase dry mouth, constipation, urinary retention, blurred vision, confusion and heat intolerance. Older adults and patients with cognitive impairment are at greatest risk of delirium and falls.
How serious is the interaction between Chlorpromazine and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity such as constipation, urinary retention and confusion, especially in elderly patients. Use the lowest effective doses or consider a less anticholinergic alternative.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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