Drug interactions
Chlorpromazine + Pasireotide
Severity: Moderate
Chlorpromazine and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide can prolong the QT interval and cause bradycardia, and chlorpromazine also prolongs QT. Together they raise the risk of ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Chlorpromazine and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Pasireotide belongs to Endocrine.
Why it happens
Additive QT prolongation, with pasireotide-related bradycardia further increasing proarrhythmic risk.
What to do
Check a baseline ECG and repeat after starting the combination. Correct hypokalemia and hypomagnesemia and monitor ECG periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Chlorpromazine with Pasireotide?
MediHelp rates the interaction as moderate. Chlorpromazine and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide can prolong the QT interval and cause bradycardia, and chlorpromazine also prolongs QT. Together they raise the risk of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Chlorpromazine and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and repeat after starting the combination. Correct hypokalemia and hypomagnesemia and monitor ECG periodically.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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