Drug interactions
Chlorpromazine + Ramipril
Severity: Moderate
Chlorpromazine and Ramipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine has alpha-adrenergic blocking activity and can cause orthostatic hypotension. Together with ramipril this may produce additive blood pressure lowering, particularly at treatment initiation or dose increases.
What this interaction means in plain words
Chlorpromazine and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Ramipril belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from alpha-1 blockade by the phenothiazine and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating either drug. Reduce the antihypertensive dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Ramipril?
MediHelp rates the interaction as moderate. Chlorpromazine and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has alpha-adrenergic blocking activity and can cause orthostatic hypotension. Together with ramipril this may produce additive blood pressure lowering, particularly at treatment initiation or dose increases.
How serious is the interaction between Chlorpromazine and Ramipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating either drug. Reduce the antihypertensive dose if symptomatic hypotension develops.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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