Drug interactions
Chlorpromazine + Salmeterol
Severity: Moderate
Chlorpromazine and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine prolongs the QT interval and salmeterol may also affect cardiac repolarization and lower potassium. Combined use may raise the risk of ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Chlorpromazine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Salmeterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia as a further contributor.
What to do
Check ECG and correct potassium and magnesium in patients with QT risk factors. Monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Salmeterol?
MediHelp rates the interaction as moderate. Chlorpromazine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine prolongs the QT interval and salmeterol may also affect cardiac repolarization and lower potassium. Combined use may raise the risk of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Chlorpromazine and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium in patients with QT risk factors. Monitor for palpitations or syncope.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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