Drug interactions
Chlorpromazine + Scopolamine
Severity: Moderate
Chlorpromazine and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine has strong anticholinergic activity, so combining it with scopolamine can cause additive effects such as dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia. Reduced gut motility from scopolamine may also alter oral chlorpromazine absorption, and sedation is additive.
What this interaction means in plain words
Chlorpromazine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade and additive sedation, with possible reduced oral absorption through slowed gastric motility.
What to do
Monitor for anticholinergic toxicity, particularly delirium, urinary retention and constipation in older patients. Use the lowest effective doses and consider a non-anticholinergic alternative where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpromazine and Scopolamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Scopolamine
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Scopolamine?
MediHelp rates the interaction as moderate. Chlorpromazine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has strong anticholinergic activity, so combining it with scopolamine can cause additive effects such as dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia. Reduced gut motility from scopolamine may also alter oral chlorpromazine absorption, and sedation is additive.
How serious is the interaction between Chlorpromazine and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, particularly delirium, urinary retention and constipation in older patients. Use the lowest effective doses and consider a non-anticholinergic alternative where possible.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
