Drug interactions
Chlorpromazine + Selpercatinib
Severity: Major
Chlorpromazine and Selpercatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so concurrent use may raise the risk of torsades de pointes and ventricular arrhythmia. The risk rises with electrolyte abnormalities, bradycardia or heart disease.
What this interaction means in plain words
Chlorpromazine and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Selpercatinib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Avoid the combination where possible; if used, monitor ECG and electrolytes regularly and correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Chlorpromazine with Selpercatinib?
MediHelp rates the interaction as major. Chlorpromazine and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so concurrent use may raise the risk of torsades de pointes and ventricular arrhythmia. The risk rises with electrolyte abnormalities, bradycardia or heart disease.
How serious is the interaction between Chlorpromazine and Selpercatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor ECG and electrolytes regularly and correct hypokalemia and hypomagnesemia.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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