Drug interactions
Chlorpromazine + Tolterodine
Severity: Moderate
Chlorpromazine and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine has significant antimuscarinic activity, so with tolterodine it can cause additive dry mouth, constipation, urinary retention, blurred vision and confusion. Both drugs can also prolong the QT interval, and chlorpromazine inhibits CYP2D6, which may raise tolterodine exposure.
What this interaction means in plain words
Chlorpromazine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects, with possible CYP2D6 inhibition by chlorpromazine raising tolterodine levels.
What to do
Monitor for anticholinergic toxicity and consider limiting the tolterodine dose if effects emerge. Check the ECG if other QT-prolonging risks are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Tolterodine?
MediHelp rates the interaction as moderate. Chlorpromazine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has significant antimuscarinic activity, so with tolterodine it can cause additive dry mouth, constipation, urinary retention, blurred vision and confusion. Both drugs can also prolong the QT interval, and chlorpromazine inhibits CYP2D6, which may raise tolterodine exposure.
How serious is the interaction between Chlorpromazine and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and consider limiting the tolterodine dose if effects emerge. Check the ECG if other QT-prolonging risks are present.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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