Drug interactions
Chlorpromazine + Tretinoin
Severity: Moderate
Chlorpromazine and Tretinoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine is a well-known photosensitizer, and systemic tretinoin also increases skin sensitivity to ultraviolet light. Together they may cause exaggerated sunburn-like or phototoxic reactions.
What this interaction means in plain words
Chlorpromazine and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Tretinoin belongs to Dermatology.
Why it happens
Additive phototoxicity through different photosensitizing mechanisms.
What to do
Counsel patients to use strict sun protection with broad-spectrum sunscreen and protective clothing. Review the skin if a reaction develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpromazine and Tretinoin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Chlorpromazine with Tretinoin?
MediHelp rates the interaction as moderate. Chlorpromazine and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine is a well-known photosensitizer, and systemic tretinoin also increases skin sensitivity to ultraviolet light. Together they may cause exaggerated sunburn-like or phototoxic reactions.
How serious is the interaction between Chlorpromazine and Tretinoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to use strict sun protection with broad-spectrum sunscreen and protective clothing. Review the skin if a reaction develops.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
